How Tiny Is The World’s Smallest Tic-Tac-Toe Game?

There are many ways to play the tic tac toe game out there. You can play on the classic pen and paper combination with a friend. You can play on mobile phones and computers with tic tac toe game software, playing against artificial intelligence. It is also possible play with a friend over the internet so that you will not have to play with artificial intelligence all the time. One of the websites to play tic tac toe with a friend or random people is However, did you know that scientists have made a new method play Tic Tac Toe, which is played using DNA? Are you wondering how does that works, and who won in the end? In this article, we will discuss just that. Without further ado, let’s start:

The world’s smallest tic tac toe game

The smallest Tic Tac Toe game in the world is played out through DNA and requires 6 full days to complete a game. The innovative method utilized to produce the game makes it possible for experts to readily change DNA structures, which is a hard thing to do. The technological innovation at the rear of this DNA modification has hands on significance, as experts are already creating and working on DNA nanotechnology that can accomplish work such as providing medications as well as arranging molecular cargo.

How it works

DNA is made up of a number of base elements known as adenine, cytosine, guanine and thymine. California Institute of Technology scientists have used the pairing mechanisms of these DNAs to adjust strands, then drive them into numerous shapes of Tic Tac Toe, like Os and Xs, as reported by the team in their study.

This method is identified as DNA origami. DNA origami was first used in 2017, making it possible for scientists to paint the tiniest version of Leonardo da Vinci’s painting “Mona Lisa”. However, it has it’s limitations back then.  It locked the genetic material strands, blocking scientists from further modifying the shapes formed by the DNA.

The Tic Tac Toe version has a work around for this problem. It employs another method known as DNA strand displacement. Using this technique, the researchers have taken advantage of DNA pairing behaviors, in which a DNA strand will form up to another pattern if it is better, which scientists have compared to dating. This way, DNA is not locked up, which is the main restriction back in 2017. This allowed for more interactive and modifiable DNA structure, which allows games like tic tac toe to be possible.

In the world’s smallest Tic Tac Toe, the DNA strand displacement operates together with self building tiles, a very easy to reproduce technology that discovers square board bits layered with special DNA strands behaving similar to a puzzle piece. A statement by the California Institute of Technology stated that every tile features its personal spot within the built 3×3 tic tac toe grid, which it alone can fit.

Who won the world’s smallest game of Tic Tac Toe

Ultimately, the game was finished after 6 days, which is the time it took the DNA strands to modify. X has won over O, setting up a perfect line of X tiles throughout the base of the 3×3 board.

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